Publications

Complete list of publications available via Pubmed

Port GC, Vega LA, Nylander AB, Caparon MG. 2014. Streptococcus pyogenes polymixin B-resistant mutants display enhanced ExPortal integrity. J Bacteriol. Epub ahead of print. Abstract

Cusumano ZT, Watsom ME Jr, Caparon MG. 2014. Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. Infect Immun. 82(1): 233-42. Abstract

Vega LA, Port GC, Caparon MG. 2013. An association between peptidoglycan synthesis and organization of the Streptococcus pyogenes ExPortal. MBio. 4(5): e00485-13. Abstract

Port GC, Paluscio E, Caparon MG. 2013. Complete genome sequence of emm Type 14 Streptococcus pyogenes strain HSC5. Genome Announc. 1(4): e00612-13. Abstract

Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. 2013. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol. 195(19): 4484-95. Abstract

Chandrasekaran S, Ghosh J, Port GC, Koh EI, Caparon MG. 2013. Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the Streptococcus pyogenes NAD+ glycohydrolase. J Biol Chem. 288(27): 20064-75. Abstract

Watson ME Jr, Nielsen HV, Hultgren SJ, Caparon MG. 2013. Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infect Immun. 81(5): 1606-17. Abstract

Cusumano Z, Caparon M. 2013. Adaptive evolution of the Streptococcus pyogenes regulatory aldolase LacD.1. J Bacteriol. 195(6): 1294-304. Abstract

Vega LA, Caparon MG. 2012. Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal. Mol Microbiol. 85(6): 1119-32. Abstract

Sperry JB, Smith CL, Caparon MG, Ellenberger T, Gross ML. 2011. Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes. Biochemistry. 50(19): 4038-45. Abstract

Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T. 2011. Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Structure. 19(2): 192-202. Abstract

Kietzman CC, Caparon MG. 2011. Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection. Infect Immun. 79(2): 812-21. Abstract

Riddle DJ, Bessen DE, Caparon MG. 2010. Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism. J Bacteriol. 192(14): 3735-46. Abstract

Magassa N, Chandrasekaran S, Caparon MG. 2010. Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O. EMBO Rep. 11(5): 400-5. Abstract

Ghosh J, Anderson PJ, Chandrasekaran S, Caparon MG. 2010. Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis. J Biol Chem. 285(8): 5683-94. Abstract

Kietzman CC, Caparon MG. 2010. CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes. Infect Immun 78(1): 241-52. Abstract

Lin A, Loughman JA, Zinselmeyer BH, Miller MJ, Caparon MG. 2009. Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection. Infect Immun. 77(11): 5190-201. Abstract

Weston BF, Brenot A, Caparon MG. 2009. The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infect Immun. 77(7): 2840-8. Abstract

Cho KH, Caparon MG. 2008. tRNA modification by GidA/MnmE is necessary for Streptococcus pyogenes virulence: a new strategy to make live attenuated strains. Infect Immun. 76(7): 3176-86. Abstract

Rosch JW, Vega LA, Beyer JM, Lin A, Caparon MG.. 2008. The signal recognition particle pathway is required for virulence in Streptococcus pyogenes. Infect Immun. 76(6): 2612-9. Abstract

Loughman JA, Caparon MG. 2007. Comparative functional analysis of the lac operons in Streptococcus pyogenes. Mol Microbiol. 64(2): 269-80. Abstract

Brenot A, Weston BF, Caparon MG. 2007. A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes. Mol Microbiol. 63(4): 1185-96. Abstract

Rosch JW, Hsu FF, Caparon MG. 2007. Anionic lipids enriched at the ExPortal of Streptococcus pyogenes. J Bacteriol. 189(3): 801-6. Abstract

Loughman JA, Caparon MG. 2007. Contribution of invariant residues to the function of Rgg family transcription regulators. J Bacteriol. 189(2): 650-5. Abstract

Loughman JA, Caparon MG. 2006. A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes. EMBO J. 25(22): 5414-22. Abstract

Ghosh J, Caparon MG. 2006. Specificity of Streptococcus pyogenes NAD+ glycohydrolase in cytolysin-mediated translocation. Mol Microbiol. 62(4): 1203-14. Abstract

Loughman JA, Caparon MG. 2006. Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: A model for in vivo gene expression. J Bacteriol. 188(2):399-408. Abstract

Meehl MA, Pinkner JS, Anderson PJ, Hultgren SJ, Caparon MG. 2005. A novel endogenous inhibitor of secreted streptococcal NAD-glycohydrolase. PLoSl. 1(4):0362-0372. Abstract

Rosch J, Caparon MG. 2005. The ExPortal: An organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes. Mol. Microbiol. 58(4):959-968. Abstract

Cho KH, Caparon MG. 2005. Patterns of virulence gene expression differ between biofilm and tisssue communities of Streptococcus pyogenes. Mol. Microbiol. 57(6):1545-56. Abstract

Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ. 2005. Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infect Immun. 73(4):2461-8. Abstract

Brenot A, King KY, Caparon MG. 2005.The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Mol. Microbiol. 55(1):221-34. Abstract

Rosch J, Caparon MG. 2004. A microdomain for protein secretion in gram-positive bacteria. Science.304(5676):1513-5 PubMed Abstract / Free Abstract / Free Full Text

Meehl MA, Caparon MG. 2004. Specificity of streptolysin O in cytolysin-mediated translocation. Mol. Microbiol. 52(6):1665-76 Abstract

Nyberg P, Sakai T, Cho KH, Caparon MG, Fassler , Bjorck L. 2004. Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes. EMBO J. 23(10): 2166-74. Abstract

Lyon WR, Caparon MG. 2004. Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S.
Infect Immun. 72(3):1618-25 Abstract

Brenot A, King KY, Janowiak B, Griffith O, Caparon MG. 2004. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect Immun. 72(1):408-13 Abstract

Neely MN, Lyon WR, Runft DL, Caparon M. 2003. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes. J Bacteriol. 185(17):5166-74 Abstract

Lyon WR, Caparon MG. 2003. Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease. J Bacteriol. 185(12):3661-7. Abstract

Neely MN, Pfeifer JD, Caparon M. 2002. Streptococcus-zebrafish model of bacterial pathogenesis. Infect Immun. 70(7):3904-14. Abstract

Gibson CM, Caparon MG. 2002. Alkaline phosphatase reporter transposon for identification of genes encoding secreted proteins in gram-positive microorganisms. Appl Environ Microbiol. 68(2):928-32. Abstract

Lyon WR, Madden JC, Levin JC, Stein JL, Caparon MG. 2001. Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes. Mol Microbiol. 42(1):145-57. Abstract

Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, Purchio TF, Caparon MG, Lipsitch M, Contag PR. 2001. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun. 69(5):3350-8. Abstract

Madden JC, Ruiz N, Caparon M. 2001. Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria. Cell. 104(1):143-52. Abstract

King KY, Horenstein JA, Caparon MG. 2000. Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes. J Bacteriol. 182(19):5290-9. Abstract

Granok A, Parsonage D, Ross RP, Caparon MG. 1999. The RofA binding site of Streptococcus pyogenes is utilized by multiple transcriptional pathways. J. Bacteriol. 182:1529-1540 Abstract

Gibson CM, Mallett TC, Claiborne A, Caparon MG. 1999. Contribution of NADH oxidase to the aerobic metabolism of Streptococcus pyogenes. J. Bacteriol. 182: 448-455 Abstract

Okada N, Tatsuno I, Hanski E, Caparon M, Sasakawa C. 1998. Streptococcus pyogenes protein F promotes invasion of HeLa cells. Microbiology. 144 ( Pt 11):3079-86. Abstract

Lyon W, Gibson C, Caparon M. 1998. A role for Trigger Factor and an Rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes. EMBO J. 21:6263-6275 Abstract

Ruiz N, Wang B, Pentland A, Caparon M. 1997. Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci. Mol. Microbiol. 27:337-346 Abstract

Okada N, Watarai M, Ozeri V, Hanski E, Caparon M, Sasakawa C. 1997. A Matrix form of fibronectin mediates enhanced binding of Streptocococcus pyogenes to host tissue. J. Biol. Chem. 272:26987-26984 Abstract

Fogg GC, Caparon MG. 1997. Constitutive expression of fibronectin-binding in Streptococcus pyogenes as a result of anaerobic activation of rofA. J. Bacteriol. 179:6172-6180 Abstract

Wang B, Ruiz N, Pentland A, Caparon M. 1997. Keratinocyte proinflammatory responses to adherent and non-adherent group A streptococci. Infect. Immun. 65:2119-2126 Abstract

Gibson CM, Caparon MG. 1996. Insertional inactivation of Streptococcus pyogenes sod suggests prtF is regulated in response to a superoxide signal. J. Bacteriol. 178:4688-4695 Abstract

Jaffe J, Natanson-Yaron S, Caparon MG, Hanski E. 1996. Protein F2, a novel fibronectin binding protein from Streptococcus pyogenes posses two binding domains. Mol. Microbiol. 21:373-384 Abstract

Ozeri V, Tovi A, Burstein I, Natanson-Yaron S, Caparon MG, Yamada KM, Akiyama SK, Vlodavsky I, Hanski E. 1996. A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix. EMBO 15:989-98 Abstract

Lee, Ju-Y, Caparon M. 1996. An oxygen-induced but protein F-independent fibronectin binding pathway in Streptococcus pyogenes. Infect. Immun. 64:413-421 Abstract

Kihlberg BM, Cooney J, Caparon MG, Olsen A, Bjorck L. 1995. Biological properties of a Streptococcus pyogenes mutant generated by Tn916 insertion in mga. Microbial Pathogenesis19:299-315 Abstract

Natanson S, Sela S, Moses A, Musser JM, Caparon MG, Hanski E. 1995. Distribution of fibronectin-binding proteins among group A streptococci of different M types. J. Infect. Dis. 171:871-878.30 Abstract

Okada N, Liszewski K, Atkinson JP, Caparon M. 1995. Membrane co-factor protein (MCP or CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. USA. 92:2489-2493 Abstract

Perez-Casal J, Okada N, Caparon M, Scott JR. 1995. Role of the conserved C repeat region of the M protein of Streptococcus pyogenes. Mol. Microbiol. 15:907-916 Abstract

Okada N, Pentland AP, Falk P, Caparon MG. 1994. M protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue. J. Clin. Invest. 94:965-977 Abstract

Fogg G, Gibson C, Caparon MG. 1994. The identification of rofA , a positive-acting regulatory component of prtF expression: Use of a mgd-based shuttle mutagenesis strategy in Streptococcus pyogenes. Mol. Microbiol. 11:671-684 Abstract

Sela S, Aviv A, Tovi A, Burstein I, Caparon MG, Hanski E. 1994. Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains at two different binding sites. Mol. Microbiol. 10:1049-1055 Abstract

Geist RT, Okada N, Caparon MG. 1993. Analysis of Streptococcus pyogenes promoters using Novel Tn916 -based shuttle vectors for the construction of transcriptional fusions to CAT. J. Bacteriol. 175:7561-7570 Abstract

VanHeyningen T, Fogg G, Yates D, Hanski E, Caparon MG. 1993. Adherence and fibronectin-binding are environmentally regulated in group A streptococci. Mol. Microbiol. 9:1213-1221 Abstract

Okada N, Geist RT, Caparon MG. 1993. Positive transcriptional control of mry regulates virulence in the group A streptococcus. Mol. Microbiol. 7:893-903 Abstract

Hanski E, Horwitz P, Caparon MG. 1992. Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells. Infect. Immun. 60:5119-5125 Abstract

Perez-Casal J, Caparon MG, Scott JR. 1992. Introduction of the emm 6 gene into an emm-deletion strain of Streptococcus pyogenes restores its ability to resist phagocytosis. Res. in Microbiol. 143:549-558 Abstract

Caparon MG, Geist RT, Perez-Casal J, Scott JR. 1992. Environmental regulation of virulence in group A streptococci: Transcription of the gene encoding the M protein is stimulated by carbon dioxide. J. Bacteriol. 174:5693-5701 Abstract

Hanski E, Caparon MG. 1992. Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus. Proc. Natl. Acad. Sci. USA. 89:6172-6176 Abstract

Perez-Casal J, Caparon MG, Scott JR. 1991. Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J. Bacteriol. 173:2617-2624 Abstract

Caparon MG, Stevens DS, Olsen A, Scott JR. 1991. Role of M protein in adherence of group A streptococci. Infect. Immun. 59:1811-1817 Abstract

Caparon MG, Scott JR. 1989. Excision and Insertion of the conjugative transposon Tn916 involves a novel recombination mechanism. Cell. 59: 1027-1034 Abstract

Norgren M, Caparon MG, Scott JR. 1989. A method for allelic replacement using the conjugative transposon Tn916: deletion of the emm 6.1 allele in Streptococcus pyogenes. Infect. Immun. 57: 3856-3862 Abstract

Scott JR, Kirchman PA, Caparon MG. 1988. An intermediate in transposition of the conjugative transposon Tn 916. Proc. Natl. Acad. USA Sci 85: 4809-4813 Abstract

Caparon MG, Johnson W. 1988. Macrophage toxicity and complement sensitivity of virulent and avirulent strains of Legionella pneumophila. Rev. Infect. Dis. 10:S377-S381 Abstract

Caparon MG, Scott JR. 1987. Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci. Proc. Natl. Acad. Sci. USA 84:8677-8681 Abstract